Endocrine Abstracts

Introduction: It has been recently suggested the genetic predisposition to obesity leads to increased risk of type 2 diabetes by its obesity predisposing effect. Surprisingly genetic loci that contribute to the development of obesity identified by genome-wide association studies (GWAS) account for only 2% of the variance in BMI. Visceral fat accumulation has an important role in increasing the risk of developing metabolic disorders, such as type 2 diabetes, dyslipidemia and CV...

Introduction: FOXP3 is a critical determinant of T regulatory cells (Tregs) development and function. Treg cells play a crucial role in modulating potentially self-reactive clones, and dysfunction of this cell type contributes to autoimmune disease such as Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). The aim of our study was to estimate the association of three polymorphism of FOXP3 gene with the predisposition to GD and HT in Polish population.<p class...